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Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists
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Structure-activity relationship of nuclear receptor-ligand interactions

Holger Greschik1, Dino Moras

  • 1Département de Biologie et Génomique Structurales, Institut de Génétique et de Biologie Moléculaire et Cellulaire, 1 rue Laurent Fries, B.P. 10142, 67404 Illkirch, France.

Current Topics in Medicinal Chemistry
|December 20, 2003
PubMed
Summary

Nuclear receptors (NRs) regulate physiological processes. Understanding the structure-activity relationship of NR-ligand interactions, especially for orphan NRs, is crucial for developing targeted therapies and advancing NR structural biology.

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