Jove
Visualize
Contact Us

Related Experiment Videos

Autophagy: a regulated bulk degradation process inside cells.

Tamotsu Yoshimori1

  • 1Department of Cell Genetics, National Institute of Genetics, Mishima, Shizuoka-ken 411-8540, Japan. tamyoshi@lab.nig.ac.jp

Biochemical and Biophysical Research Communications
|December 20, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Selective autophagy receptors: Multifunctional regulators of organelle turnover.

Current opinion in cell biology·2026
Same author

Autophagy-Independent Function of ATG-18 Is Essential for Gonadal Longevity in Caenorhabditis elegans.

Aging cell·2026
Same author

Molecular mechanisms of the lysosomal damage response and its roles in aging and disease.

Journal of cell science·2025
Same author

Towards global healthy longevity: report from the 1st World Longevity Summit in Kyotango, Japan.

npj aging·2025
Same author

ATG conjugation-dependent/independent mechanisms underlie lysosomal stress-induced TFEB regulation.

The Journal of cell biology·2025
Same author

Novel insights into the molecular mechanism of amphisome-lysosome fusion.

Autophagy reports·2025
Same journal

SMURF1-mediated EFEMP1 ubiquitination reverses the resistance of HCC cells to sorafenib by promoting ferroptosis.

Biochemical and biophysical research communications·2026
Same journal

Development and validation of HSP90AA1 as a risk gene in a HIF-1α pathway-related prognostic signature for hepatocellular carcinoma.

Biochemical and biophysical research communications·2026
Same journal

Quercetin suppresses TGF-β1-induced proliferation and migration of vascular smooth muscle cells via the Smad2/3/MMP-9 signaling axis.

Biochemical and biophysical research communications·2026
Same journal

Biosynthesis, characterization and biological potential of microbe-mediated silver nanoparticles using thermophilic actinomycetes, Streptomyces nigra.

Biochemical and biophysical research communications·2026
Same journal

COP9 signalosome 8 mediated autophagy drives proliferation, invasion, and metastasis in pancreatic ductal adenocarcinoma.

Biochemical and biophysical research communications·2026
Same journal

Tumor budding in colorectal cancer: partial EMT, microenvironmental remodeling, and metastatic competence.

Biochemical and biophysical research communications·2026
See all related articles
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Autophagy is a vital cellular process for degrading and recycling components using autophagosomes. Recent research illuminates the molecular mechanisms behind its membrane dynamics and regulation, especially during starvation.

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Biochemistry

Background:

  • Autophagy is a fundamental intracellular degradation and recycling pathway conserved in eukaryotic cells.
  • This process involves the formation of double-membrane vesicles called autophagosomes to deliver cellular material to lysosomes for breakdown.
  • Autophagy plays a crucial role in cellular homeostasis, particularly under nutrient deprivation, by maintaining essential amino acid levels for protein synthesis.

Purpose of the Study:

  • To elucidate the molecular mechanisms governing the membrane dynamics during autophagy.
  • To understand the regulatory pathways controlling the autophagic process.
  • To provide new insights into how autophagy is activated, especially under starvation conditions.

Main Methods:

Related Experiment Videos

  • The study likely involved advanced microscopy techniques to visualize autophagosome formation and trafficking.
  • Molecular biology approaches were probably used to identify and characterize key proteins involved in autophagy regulation.
  • Biochemical assays may have been employed to study the interactions and functions of these proteins.

    • Main Results:

    • Significant progress has been made in understanding the complex membrane trafficking events essential for autophagosome biogenesis.
    • Key regulatory factors controlling the initiation and execution of autophagy have been identified.
    • The molecular basis for the induction of autophagy during starvation has been further clarified.

    Conclusions:

    • Recent advancements have significantly demystified the long-standing questions surrounding the molecular regulation and membrane dynamics of autophagy.
    • Understanding these processes is critical for comprehending cellular adaptation to stress and maintaining overall cell health.
    • Further research in this area holds potential for therapeutic interventions targeting diseases associated with autophagic dysfunction.