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Updated: Aug 29, 2026

In Vivo Imaging of Transduction Efficiencies of Cardiac Targeting Peptide
Published on: June 11, 2020
In vitro gene delivery by a novel human calcitonin (hCT)-derived carrier peptide
Ulrike Krauss1, Martin Müller, Michael Stahl
1Institute of Biochemistry, University of Leipzig, Brüderstrasse 34, 04103 Leipzig, Germany.
Abstract:
Gene therapy still awaits a broader application, since safe and efficient gene delivery is a major problem. Also for the investigation of signal transduction and intracellular trafficking, delivery systems for hydrophilic macromolecules that are easy to use are needed. Several peptide-based delivery systems have been developed during the last years. We present here a novel carrier peptide derived from human calcitonin that is capable of transfecting human neuroblastoma cells by complex formation with a plasmid. Because of the peptide's physiological origin, cytotoxic effects are not expected.
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