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Phenolic thiazoles as novel orally-active neuroprotective agents

Jeremiah J Harnett¹, Veronique Roubert, Christine Dolo

¹Department of Medicinal Chemistry, Ipsen Research Laboratories, Institute Henri Beaufour, 5 Avenue du Canada, 91966 Les Ulis Cedex, France. jeremiah.harnett@ipsen.com

Bioorganic & Medicinal Chemistry Letters

|December 20, 2003

Abstract:

Novel phenolic thiazoles compounds were prepared which demonstrated potent antioxidant activity and potent in vivo neuroprotection in mitochondrial toxin models and also possess good oral bioavailability.

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