Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Rational conversion from antiepileptic polytherapy to monotherapy.

Michel Baulac1

  • 1University Paris VI, Epilepsy Department Hospital Pitié-Salpêtrière and INSERM 0224, France. michel.baulac@psl.ap-hop-paris.fr

Epileptic Disorders : International Epilepsy Journal with Videotape
|December 20, 2003
PubMed
Summary

For epilepsy patients with poorly controlled seizures, switching from multiple antiepileptic drugs (AEDs) to a single AED can be successful. This conversion may improve seizure control while minimizing adverse effects.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

FDA safety warning on the cardiac effects of lamotrigine: An advisory from the Ad Hoc ILAE/AES Task Force.

Epilepsia open·2021
Same author

FDA Safety Warning on the Cardiac Effects of Lamotrigine: An Advisory From the Ad Hoc ILAE/AES Task Force.

Epilepsy currents·2021
Same author

Safety, tolerability, and efficacy of brivaracetam as adjunctive therapy in patients with focal seizures, generalized onset seizures, or Unverricht-Lundborg disease: An open-label, long-term follow-up trial.

Epilepsy research·2021
Same author

Understanding the challenge of comparative effectiveness research in focal epilepsy: A review of network meta-analyses and real-world evidence on antiepileptic drugs.

Epilepsia·2020
Same author

Loss-of-Function Mutations in NR4A2 Cause Dopa-Responsive Dystonia Parkinsonism.

Movement disorders : official journal of the Movement Disorder Society·2020
Same author

Conscious and unconscious expectancy effects: A behavioral, scalp and intracranial electroencephalography study.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology·2019

Area of Science:

  • Neurology
  • Pharmacology
  • Clinical Medicine

Background:

  • Epilepsy treatment aims for seizure freedom with minimal adverse events.
  • Most newly diagnosed patients achieve control with single antiepileptic drug (AED) therapy.
  • 30-40% of patients have poorly controlled epilepsy, often managed with add-on AEDs (polytherapy).

Purpose of the Study:

  • To address the clinical challenge of converting patients with epilepsy from polytherapy to monotherapy.
  • To evaluate the feasibility and outcomes of switching from multiple AEDs to a single AED regimen.
  • To provide guidance on managing polytherapy to monotherapy conversion in epilepsy.

Main Methods:

  • Review of evidence from studies using standard and new antiepileptic drugs.
  • Analysis of successful conversion strategies from polytherapy to monotherapy.

Related Experiment Videos

  • Consideration of factors influencing drug withdrawal and continuation for monotherapy.

    • Main Results:

    • Selected patients, even with previously resistant epilepsy, can be converted from polytherapy to monotherapy.
    • Successful conversions maintain or improve seizure control.
    • Adverse effects can be minimized through gradual drug withdrawal and dose adjustment.

    Conclusions:

    • Converting epilepsy patients from polytherapy to monotherapy is a viable strategy.
    • Careful patient selection and management are crucial for successful conversion.
    • Monotherapy can be achieved without compromising seizure control, potentially with improved outcomes and reduced toxicity.