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Lysine kinetics in preterm infants: the importance of enteral feeding

S R D van der Schoor1, P J Reeds, F Stellaard

  • 1Erasmus MC-Sophia Children's Hospital, Department of Paediatrics, Dr Molewaterplein 60, 3015 GJ, Rotterdam, The Netherlands.

Gut
|December 20, 2003
PubMed

Insights

First pass lysine metabolism in preterm infants is higher with partial enteral feeding. Full enteral feeding improves lysine balance and protein deposition compared to parenteral administration.

Area of Science:

  • Biochemistry
  • Neonatal Nutrition
  • Pediatric Gastroenterology

Background:

  • Lysine is an essential amino acid crucial for newborn development.
  • Intestinal first-pass metabolism significantly impacts systemic lysine availability.
  • Understanding lysine metabolism in preterm infants is vital, especially with varying enteral intake levels.

Purpose of the Study:

  • To investigate the extent of intestinal first-pass lysine metabolism in preterm infants.
  • To compare lysine kinetics under partial versus full enteral feeding conditions.
  • To determine the impact of feeding method on lysine utilization and balance in preterm neonates.

Main Methods:

  • Study involved six preterm infants with low birth weight.
  • Dual stable isotope tracer techniques were employed to measure lysine kinetics.
  • Infants were assessed during two feeding periods: 40% enteral/60% parenteral and 100% enteral feeding.

Main Results:

  • Fractional intestinal lysine uptake was significantly higher during partial enteral feeding (32% vs. 18%).
  • Absolute lysine uptake did not differ significantly between feeding groups.
  • Whole body lysine oxidation decreased, and lysine balance improved with full enteral feeding.

Conclusions:

  • Preterm infants exhibit higher fractional intestinal lysine uptake during partial enteral feeding.
  • Full enteral feeding enhances lysine utilization, reducing oxidation and improving net balance.
  • Dietary lysine is more effective than parenteral lysine in promoting protein deposition in preterm infants.
Abstract

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