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[Immunotherapy by Japanese cedarpollen in atpic dermatitis]
Fumiko Juji1, Shigetoshi Kobayashi, Shigeru Ito
1Japan Clinical Allergy Institute, Shinbashi Allergy and Rheumatismus Clinic.
Arerugi = [Allergy]
|December 20, 2003
Summary
Japanese cedar pollen immunotherapy significantly reduced allergic reactions in atopic dermatitis patients. Hyposensitization therapy led to decreased symptom severity and recurrence, showing promise for effective treatment.
Area of Science:
- Immunology
- Allergology
- Dermatology
Background:
- Atopic dermatitis patients often experience symptom exacerbation during Japanese cedar pollen season.
- Elevated immune responses to Japanese cedar pollen are common in affected individuals.
Purpose of the Study:
- To evaluate the efficacy of Japanese cedar pollen hyposensitization therapy in atopic dermatitis patients.
- To assess changes in immune cell stimulation indices and clinical symptoms post-therapy.
Main Methods:
- Radioallergosorbent test (RAST) and Cellular Antigen Stimulation Test (CAST) were used to assess allergic sensitization.
- Immune cell stimulation indices were measured using Cry j 1 allergen and anti-IgE.
- Symptom scores were evaluated using the Rajka & Langeland criteria.
Main Results:
- Hyposensitized patients exhibited significantly lower stimulation indices compared to non-hyposensitized controls.
- One year of hyposensitization therapy led to a significant decrease (approx. 65%) in Cry j 1-induced stimulation indices.
- Anti-IgE induced stimulation also decreased significantly (approx. 80%) post-therapy, correlating with symptom improvement.
Conclusions:
- Japanese cedar pollen hyposensitization is a promising therapeutic approach for atopic dermatitis.
- The treatment effectively reduces allergic immune responses and alleviates clinical symptoms, minimizing symptom recurrence.