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Related Experiment Videos

Intraneural synovial sarcoma: two cases.

Peiguo G Chu1, Jean Benhattar, Lawrence M Weiss

  • 1Division of Pathology, City of Hope National Medical Center, Duarte, CA 91010, USA. pchu@coh.org

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
|December 20, 2003
PubMed
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We present two rare cases of intraneural synovial sarcoma, a soft-tissue tumor occurring within nerves. Molecular studies confirmed the characteristic SYT-SSX translocation in both biphasic and monophasic variants.

Area of Science:

  • Oncology
  • Pathology
  • Neurology

Background:

  • Synovial sarcoma is a rare soft-tissue sarcoma.
  • Intraneural occurrence is exceptionally uncommon.
  • Accurate diagnosis requires comprehensive histopathological and molecular analysis.

Observation:

  • Two cases of intraneural synovial sarcoma are reported.
  • Case 1: 46-year-old female with an infra-auricular soft-tissue mass.
  • Case 2: 11-year-old girl with C7 spinal root pain and a nerve root foramina nodule.

Findings:

  • Both lesions were small and showed features of synovial sarcoma.
  • Case 1: Biphasic variant; Case 2: Monophasic variant.
  • Immunohistochemistry and ultrastructural studies excluded schwannoma and malignant peripheral nerve sheath tumors.

Related Experiment Videos

  • Molecular studies confirmed the characteristic t(X;18)(SYT-SSX) translocation in both cases.

    • Implications:

    • This report expands the understanding of synovial sarcoma presentation.
    • Highlights the importance of considering rare diagnoses in nerve-related masses.
    • Emphasizes the utility of integrated diagnostic approaches for accurate classification.