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Efficient syntheses of pterulone, pterulone B and related analogues
Philippe Lemaire1, Geneviève Balme, Philippe Desbordes
1Laboratoire de Chimie Organique 1, CNRS UMR 5622, Université Claude Bernard, Lyon I, CPE. 43, Bd du 11 Novembre 1918, 69622 Villeurbanne, France.
Organic & Biomolecular Chemistry
|December 20, 2003
Abstract:
An efficient synthesis of the three halogenated naturally occurring products, pterulone (2), pterulone B (3) and alcohol 5, and of a wide range of related unnatural analogues has been achieved starting from the two readily available 1-benzoxepine sulfonyl-containing intermediates 6a and 6b. The biological activities of pterulone and some of the synthesized analogues were tested against a wide spectrum of phytopathogenic fungi.