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Updated: Aug 7, 2026

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
Published on: November 20, 2015
[Prolonged rupture of the membranes and neonatal infection]
M M Mataloun1, E A Prescinotti, R A Arcas
1Instituto da Criança Professor Pedro de Alcantara, FMUSP.
Objective:
To evaluate a schedule of assessment at birth of newborn from mothers with prolonged rupture of membranes (PROM >or= 24 hours), based on selected clinical and laboratorial parameters of infection.
Methods:
Prospective study, including newborns admitted to the Nursery of the Hospital de Clínicas - University of São Paulo from May/1993 to December / 1994, whose mothers had PROM >/or 24 hours. In all newborns white blood cell count (umbilical cord and 24 hours of life) and blood culture of umbilical cord were done. Antibiotics were given to newborns with clinical signs of chorioamnionitis, GA
Results:
The incidence of infection was 38.1% and was more frequent in newborns with GA < 34 weeks (p< 0.05). No statistical significance was noted among the subgroups analysed. Among the risk factors analysed, GA < 34 weeks was the main one.
Conclusions:
The authors recommend the use of prophylactic antibiotic therapy in newborns from mothers with PROM which have a GA
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