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Published on: December 17, 2017
[Factors related to severe acute asthma in childhood - epidemiologic and clinical aspects]
J C Santana1, S S Barreto, P R Carvalho
1Médico Pediatra Intensivista do Hosp. São Lucas-PUCRS, UFRGS.
Insights
Severe acute asthma in children admitted to the pediatric intensive care unit (PICU) is linked to young age, family history of asthma or smoking, and prior hospitalizations. Effective medical care and early intervention are crucial for better outcomes.
Area of Science:
- Pediatric Pulmonology
- Epidemiology
- Critical Care Medicine
Context:
- Severe acute asthma necessitates pediatric intensive care unit (PICU) admission.
- Understanding risk factors for severe asthma in children is crucial for effective management.
- This study investigates epidemiologic and clinical factors associated with severe asthma in PICU admissions.
Purpose:
- To identify epidemiologic and clinical factors associated with severe acute asthma in children requiring PICU admission.
- To analyze precipitating factors, family history, and clinical course of severe asthma in pediatric patients.
- To determine factors influencing hospitalization duration and complications like pneumonitis.
Summary:
- Respiratory viral infections were the primary trigger for severe asthma attacks in 74% of cases.
- A family history of asthma, atopy, or smoking was present in 97% of children.
- Younger age (under 1 year), previous PICU admission, family history of smoking, and pneumonitis were associated with longer PICU stays.
- Pneumonitis was a common complication, particularly in infants under one year receiving public healthcare.
Impact:
- Identifies key risk factors for severe pediatric asthma, including age, family history, and prior hospitalizations.
- Highlights the significant role of viral infections and pneumonitis in severe asthma exacerbations.
- Suggests that early and aggressive management, alongside effective medical care, can improve clinical outcomes for children with severe acute asthma.
- Emphasizes the low mortality rate for children with acute asthma requiring PICU admission.
Objective:
To study the epidemiologic and clinical factors related to severe acute asthma in patients hospitalized in pediatric intensive care unit (PICU). STUDY PROFILE: Prospective, epidemiologic. All admissions were observed.
Patients And Methods:
All children with severe asthma admitted to PICU-HSL-PUCRS between January, 1994, and December, 1994. Their parents were asked to answer a questionnaire about clinical history and precipitating factors of bronchospasm. Clinical evolution was observed in each patient.
Results:
31 children were admitted on 42 occasions to the PICU for the treatment of severe asthma (7.3% of all admissions). The male: female ratio was 1.2:1.0 and the age mean was 25 months. Respiratory viral infections were the main precipitating factor of asthma attacks (74%). Family history of asthma, atopy or tabagism were observed in 97% of the cases. A longer hospitalization period was associated with less than 1 year age (p=0.0005), family history of tabagism (OR= 2.3) and occurrence of pneumonitis (p= 0.03). The long stay in PICU was associated with previous PICU admission (p=0.03), family history of tabagism (OR=2.0) and occurrence of pneumonitis (p=0.02). The main complication observed, especially in patients under 1 year receiving public health care, was pneumonitis, that was diagnosed in 42% of these children. Patients assisted by a private doctor had a shorter hospitalization period and less pneumonitis complication. Mechanical ventilation was necessary in 10% of these patients. There was no death in our series.
Conclusions:
The incidence of severe acute asthma, associated with long staying in PICU and hospitalization, is related to low age (under 1 year), previous hospitalization due to bronchospasm, family history of asthma, atopy or tabagism, and ineffective medical care. These factors seem related to frequent crises causing more hospitalization indications. These children frequently present pneumonitis during their clinical evolution. Early and aggressive management in general benefit the clinical course of severe acute asthma. The mortality ratio for children with acute asthma who need PICU admissions is small.
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