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Protocol for Plasmodium falciparum Infections in Mosquitoes and Infection Phenotype Determination
Published on: July 4, 2007
[Plasmodium vivax malaria in children and adolescents - epidemiological, clinical and laboratory features]
A M Ventura1, A Y Pinto, R S Silva
1Universidade Estadual do Pará, Belém, PA, Brazil.
Insights
Plasmodium vivax malaria commonly affects children and adolescents, with fever as a primary symptom. Delayed diagnosis worsens anemia, highlighting the need for prompt clinical and epidemiological assessment.
Area of Science:
- Tropical Medicine
- Pediatric Infectious Diseases
- Epidemiology
Background:
- Plasmodium vivax malaria presents unique challenges in pediatric populations.
- Understanding its epidemiological, clinical, and laboratory features is crucial for effective management.
Purpose of the Study:
- To evaluate the epidemiological, clinical, and laboratory characteristics of Plasmodium vivax malaria in children and adolescents.
- To identify factors influencing disease presentation and outcomes.
Main Methods:
- Retrospective analysis of 100 children and adolescents diagnosed with P. vivax malaria.
- Data collection included epidemiological, clinical, and laboratory parameters.
- Statistical analysis to determine correlations and significant associations.
Main Results:
- Malaria incidence was higher in adolescents, with most infections occurring in Pará State.
- Fever (88%) was the predominant initial symptom; typical paroxysms were infrequent (25%).
- Pallor was significantly associated with anemia, and delayed diagnosis correlated with lower hemoglobin levels.
Conclusions:
- Plasmodium vivax malaria affects both sexes in children and adolescents.
- Epidemiological and clinical data are vital for early diagnosis.
- Delayed diagnosis exacerbates anemia in pediatric malaria patients.
Abstract:
OBJECTIVE: Evaluation of epidemiological, clinical and laboratory features of Plasmodium vivax malaria in children and adolescents. METHODS: This study was carried out in the Malaria Program of the Evandro Chagas Institute (Belém, Pará), from January 1995 to November 1996. 100 children and adolescents with the diagnosis of P. vivax malaria (thick blood film) were randomly enrolled. A protocol was created to assess epidemiological, clinical and laboratory parameters of this pathology. RESULTS: Malaria occurred in both sexes, and had a prevailing incidence among adolescents (37%). Most of the children and adolescents (92%) had been infected in the State of Pará. Autochthonous cases in the metropolitan area of Belém accounted for 34 % of the sample. Primary infection was seen in 80% of the patients. Fever was the major onset clinical symptom (88%). A history of typical febrile paroxysm was recorded in only 25% of the casuistic. In the first day of treatment (D0) fever (97%), chills (91%), pallor (85%), splenomegaly (46%) and hepatomegaly (29%) were some of the clinical features observed. Pallor (clinical signal) was found to be significantly (p=0.0004) associated with anemia (hemoglobin rate). There was a high significant negative correlation (p=0.0001) between delay of diagnosis (mean 12,5 days) and hemoglobin values. Regarding parasitological examination, just children and adolescents with positive results to hookworms were significantly (p=0.0133, p=0.0075) more anemic than those who had a positive parasitological examination to other helminths and/or protozoa species. CONCLUSIONS: Malaria affected children and adolescents from both sexes. An emphasis on epidemiological and clinical data is an important tool to the precocious diagnosis of the disease. Delay on diagnosis made anemia worse.
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