[Cisapride related movement disorders]

Area of Science:

• Pediatric Neurology
• Clinical Pharmacology

Background:

• Gastroesophageal reflux disease (GERD) is common in infants.
• Cisapride has been used to manage GERD.
• Adverse neurological events associated with cisapride are rare but significant.

Purpose of the Study:

• To report a case of movement disorder in an infant treated with cisapride.
• To highlight the potential neurological side effects of cisapride.

Main Methods:

• A case report methodology was employed.
• Detailed clinical observation and neurological examination were performed.
• Exclusion of other potential etiologies (metabolic, toxic, infectious) was conducted.

Main Results:

• An 8-month-old male infant developed repetitive hand and foot movements after initiating cisapride for GERD.
• The movement disorder correlated with cisapride dosage.
• Neurological evaluation revealed an absent parachute reflex.
• Discontinuation of cisapride resulted in complete resolution of symptoms within 30 days.

Conclusions:

• Cisapride can be associated with new-onset involuntary movements in infants.
• Neurological symptoms such as seizures, somnolence, malaise, or involuntary movements warrant consideration for cisapride discontinuation.
• Careful monitoring for adverse neurological effects is crucial in patients receiving cisapride.