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[Cisapride related movement disorders]

R Lucena1, L Monteiro, A Melo

  • 1Universidade Federal da Bahia (UFBA), Salvador, BA, Brazil.

Jornal De Pediatria
|December 20, 2003
PubMed
Summary

Cisapride, a medication for gastroesophageal reflux disease, was linked to new-onset involuntary movements in an infant. Discontinuing cisapride led to the resolution of these concerning neurological symptoms.

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Area of Science:

  • Pediatric Neurology
  • Clinical Pharmacology

Background:

  • Gastroesophageal reflux disease (GERD) is common in infants.
  • Cisapride has been used to manage GERD.
  • Adverse neurological events associated with cisapride are rare but significant.

Purpose of the Study:

  • To report a case of movement disorder in an infant treated with cisapride.
  • To highlight the potential neurological side effects of cisapride.

Main Methods:

  • A case report methodology was employed.
  • Detailed clinical observation and neurological examination were performed.
  • Exclusion of other potential etiologies (metabolic, toxic, infectious) was conducted.

Main Results:

  • An 8-month-old male infant developed repetitive hand and foot movements after initiating cisapride for GERD.
  • The movement disorder correlated with cisapride dosage.
  • Neurological evaluation revealed an absent parachute reflex.
  • Discontinuation of cisapride resulted in complete resolution of symptoms within 30 days.

Conclusions:

  • Cisapride can be associated with new-onset involuntary movements in infants.
  • Neurological symptoms such as seizures, somnolence, malaise, or involuntary movements warrant consideration for cisapride discontinuation.
  • Careful monitoring for adverse neurological effects is crucial in patients receiving cisapride.

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