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Studies of oxidative stress in cellular systems. The interaction of monocytes and erythrocytes
P E McGowan1, J Reglinski, W E Smith
1Department of Pure and Applied Chemistry, Strathclyde University, Glasgow, UK.
FEBS Letters
|December 21, 1992
Abstract:
1H spin echo NMR spectroscopy is used to follow the interaction of intact and viable erythrocytes and monocytes obtained from different sources in mixed cultures. After a lag time (270 min) erythrocyte glutathione is observed to become more oxidised. This result is believed to occur as a consequence of monocyte activation generating hydrogen peroxide or hypochlorous acid, which is targeted at the erythrocyte. The red cell in turn employs its sulphydryl system as an anti-oxidant defence.