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Primary orbital plasmacytoma: A case report.

Seema Sen1, Seema Kashyap, Subhash Betharia

  • 1Department of Ocular Pathology, Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, India. ssenop@rediffmail.com

Orbit (Amsterdam, Netherlands)
|December 20, 2003
PubMed
Summary
This summary is machine-generated.

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A rare solitary plasmacytoma in the eye required orbital exenteration after radiotherapy proved insufficient. Immunohistochemical stains confirmed the diagnosis, highlighting their importance in identifying ocular plasmacytomas.

Area of Science:

  • Ophthalmology
  • Oncology
  • Pathology

Background:

  • Solitary plasmacytomas are rare plasma cell neoplasms.
  • Ocular involvement is uncommon, presenting diagnostic challenges.
  • Distinguishing from multiple myeloma is crucial for management.

Observation:

  • A 50-year-old male presented with a fungating left eye mass of 3 months duration.
  • Initial biopsy suggested plasmacytoma, confirmed by immunohistochemistry showing kappa light chain monoclonality.
  • Systemic evaluation excluded multiple myeloma.

Findings:

  • The ocular plasmacytoma was not fully radiosensitive, necessitating left orbital exenteration due to residual disease.
  • Immunohistochemical staining for kappa and lambda light chains was vital for confirming the diagnosis.

Related Experiment Videos

  • This case underscores that solitary plasmacytomas may require radical surgical intervention.

    • Implications:

    • Ocular plasmacytomas can be aggressive and may not respond completely to radiotherapy.
    • Radical surgery, such as orbital exenteration, may be necessary for treatment.
    • Accurate diagnosis via immunohistochemistry is critical for appropriate patient management and prognosis.