Ethics and Bioethics
Ethical Issues
Ethical Dilemmas I
Ethical Dilemmas II
Methods of Documentation V: CBE
Nursing Ethical Principles I
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Updated: Feb 24, 2026

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
Ann E Mills1, Edward M Spencer
1Center for Biomedical Ethics, University of Virginia, P.O. Box 800758, Charlottesville, VA 22908-0758, USA. amh2r@virginia.edu
Evidence-based medicine (EBM) implementation faces challenges due to healthcare cost pressures, favoring rigid systems over adaptive ones. Clinical ethicists must understand these systems to advocate for patient values within EBM.
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