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Inactivation of the fis gene leads to reduced growth rate
L Nilsson1, H Verbeek, U Hoffmann
1Department of Cell Biology, Arrhenius Laboratories, Stockholm University, Sweden.
FEMS Microbiology Letters
|November 15, 1992
Abstract:
The FIS protein (factor for inversion stimulation) is known to activate the transcription of rRNA and tRNA operons in Escherichia coli. In this report the growth behaviour of a fis bacterium was studied under steady-state conditions and in competition experiments with a wild-type bacterium in a chemostat. The growth rate of the fis bacterium was reduced as compared to that of an isogenic wild-type and this reduction increased linearly with increasing growth rate. A similar result was obtained in competition experiments in a chemostat, with the selection factor increasing linearly with the growth rate.