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Is this patient insulin resistant? How much does it matter?
Jeanelle Sheeder1, Sharon H Travers, Catherine Stevens-Simon
1Department of Pediatrics, University of Colorado Health Science Center, The Children's Hospital, Denver, Colorado 80218, USA.
Clinical Pediatrics
|December 23, 2003
Summary
This case study discusses a 10-year-old girl with obesity and a family history of diabetes. It explores the diagnosis and management of insulin resistance (IR) in pediatric patients.
Area of Science:
- Pediatric Endocrinology
- Metabolic Disorders
- Clinical Case Study
Background:
- Obesity in children is a growing concern, often linked to metabolic complications.
- Family history of type 2 diabetes, hypertension, and PCOS increases risk.
- Early identification of metabolic dysfunction is crucial for long-term health.
Observation:
- A 10-year-old obese female presented with central adiposity and acanthosis nigricans.
- Initial lab work ruled out diabetes and glucose intolerance.
- Clinical signs suggested potential insulin resistance (IR).
Findings:
- The case highlights the diagnostic challenge of isolated insulin resistance in youth.
- Acanthosis nigricans and central obesity are key indicators of IR.
- Further evaluation may be warranted despite normal glucose tolerance tests.
Implications:
- Early diagnosis and management of pediatric IR can prevent progression to type 2 diabetes.
- Lifestyle interventions are key for managing pediatric IR.
- Understanding IR pathophysiology is vital for effective treatment strategies.