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Correlation in ages at death from familial ovarian cancer among sisters
R S Houlston1, J Hampson, W P Collins
1Department of Clinical Genetics, Royal Free Hospital School of Medicine, London, United Kingdom.
Gynecologic Oncology
|November 1, 1992
Abstract:
The analysis of pedigrees taken from 97 of 1466 women attending a screening clinic for early familial ovarian cancer showed that there was a strong correlation in the ages at death from the disease among sisters (r = 0.68, confidence limits 0.51-0.82, P < 0.001), but not between mothers and daughters. This information can be used to help counsel women who are considering the appropriate time for more intensive screening or prophylactic oophorectomy.