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Related Experiment Videos

Choroidal neovascularization is provided by bone marrow cells.

Minoru Tomita1, Haruhiko Yamada, Yasushi Adachi

  • 1First Department of Pathology, Kansai Medical University, Moriguchi City, Osaka, Japan.

Stem Cells (Dayton, Ohio)
|December 23, 2003
PubMed
Summary

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Bone marrow cells (BMCs) can form new blood vessels in choroidal neovascularization (CNV), a cause of age-related macular degeneration (ARMD). Inhibiting endothelial progenitor cell (EPC) mobilization may offer a new treatment for ARMD with CNV.

Area of Science:

  • Ophthalmology
  • Regenerative Medicine
  • Vascular Biology

Background:

  • Choroidal neovascularization (CNV) is a leading cause of blindness in age-related macular degeneration (ARMD).
  • Bone marrow cells (BMCs) contain hematopoietic stem cells and endothelial progenitor cells (EPCs) with regenerative potential.
  • EPCs are implicated in neovascularization processes.

Purpose of the Study:

  • To investigate the role of BMCs in the development of CNV.
  • To determine if BMCs contribute to the neovascularization in a mouse model of CNV.

Main Methods:

  • Induced CNV in adult mice using laser photocoagulation.
  • Performed bone marrow transplantation (BMT) using BMCs from enhanced green fluorescent protein (EGFP)-expressing donor mice.
  • Analyzed CNV lesions in chimeric mice via immunohistochemistry for EGFP and CD31 expression.

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Main Results:

  • Chimeric mice showed successful engraftment of donor BMCs (>95%).
  • Vascular wall cells within the CNV lesions expressed both EGFP and CD31.
  • This indicates that newly formed blood vessels in CNV originate from BMCs.

Conclusions:

  • BMCs, specifically EPCs, contribute to the formation of new blood vessels in CNV.
  • Inhibiting EPC mobilization from bone marrow to the eye may represent a novel therapeutic strategy for ARMD-related CNV.