Related Experiment Video
Updated: Aug 29, 2026
Intraoperative Visualization of Subretinal Injection and Retinal Detachment in Rats
Published on: March 7, 2025
Intravitreal r-TPA and gas injection in traumatic submacular hemorrhage
Detlef Holland1, Burkhard Wiechens
1Department of Ophthalmology, Christian Albrechts University Kiel, Kiel, Germany. dholland@ophthalmol.uni-kiel.de
Aim:
To present the technique and efficiency of intravitreal recombinant tissue plasminogen activator (r-TPA) and gas injection in acute submacular hemorrhage (SMH) due to traumatic choroidal rupture.
Patients And Methods:
0.4 ml of sulfur hexafluoride was injected into the vitreous cavity in 2 patients with SMH due to traumatic choroidal rupture. In 1 patient gas injection was combined with 50 microg r-TPA. Both patients were closely followed.
Results:
Preoperative visual acuity was 20/125 in one eye and 20/100 in the other. At the end of the follow-up, visual acuity had improved to 20/32 in both eyes.
Conclusion:
r-TPA and gas injection into the vitreous body may be an efficient therapy in patients with submacular hemorrhage due to choroidal rupture.
