Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Classifying hepatitis B virus genotypes.

Yuzo Miyakawa1, Masashi Mizokami

  • 1Miyakawa Memorial Research Foundation, Minami-Aoyama 2-19-8, Minato-ku, Tokyo 107-0062, Japan. miyafdn@po.iijnet.or.jp

Intervirology
|December 23, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Long non-coding RNA PWRN4 associated with post-SVR hepatocellular carcinoma: a genome-wide association study.

Biomarker research·2025
Same author

Human Leukocyte Antigen Genotypes Affect Hepatitis B Virus Mutations Associated With Hepatocellular Carcinoma.

Hepatology research : the official journal of the Japan Society of Hepatology·2025
Same author

Structural basis of the hepatitis B virus X protein in complex with DDB1.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

CXCL13 and CCL21 Induce Tertiary Lymphoid Structures and Enhance the Efficacy of Immunotherapy for Melanoma.

Cancer science·2025
Same author

Identification of glycogen synthase kinase 3alpha/beta as a host factor required for HBV transcription using high-throughput screening.

Hepatology (Baltimore, Md.)·2025
Same author

M2BPgs-HCC: An Automated Multilectin Bead Array Indicating Aberrant Glycosylation Signatures Toward Hepatitis C Virus-Associated Hepatocellular Carcinoma Prognosis.

Molecules (Basel, Switzerland)·2024

Hepatitis B virus (HBV) has eight genotypes (A-H) with distinct global distributions and clinical implications. Understanding HBV genotypes is crucial for disease progression and antiviral treatment effectiveness.

Area of Science:

  • * Virology
  • * Infectious Diseases
  • * Epidemiology

Background:

  • * Hepatitis B virus (HBV) was initially classified into four genotypes (A-D) in 1988 based on genomic sequence divergence.
  • * Currently, seven HBV genotypes (A-G) are recognized, with an eighth emerging, each exhibiting unique geographical distributions worldwide.
  • * Coinfection with multiple HBV genotypes occurs in approximately 10% of infected individuals, facilitating intertypic recombination.

Purpose of the Study:

  • * To review the current understanding of HBV genotypes, their geographical distribution, and their impact on disease progression and treatment.
  • * To highlight the clinical significance of HBV genotype classification, including the need for further subtyping.

Main Methods:

  • * Review of existing literature on HBV genotype classification, distribution, and clinical relevance.

Related Experiment Videos

  • * Analysis of sequence divergence data for HBV genome classification.
  • * Examination of the influence of specific HBV genotypes on hepatitis B e antigen (HBeAg) seroconversion and disease outcomes.

    • Main Results:

    • * HBV genotypes A-G have distinct geographical prevalences (e.g., Genotype A in Europe/Americas, B/C in Asia, D in Mediterranean/Asia, E in West Africa, F in Central/South America).
    • * A specific mutation (G1896A) leading to a stop codon is prohibited in certain genotypes (A, some C/F) due to a complementary nucleotide at position 1858, affecting HBeAg seroconversion.
    • * Emerging evidence indicates that HBV genotypes influence chronic hepatitis B progression and response to antiviral therapies.

    Conclusions:

    • * HBV genotype classification is essential for understanding global epidemiology and clinical management of hepatitis B.
    • * Further subtyping of HBV genotypes may be necessary to capture clinically relevant variations.
    • * The geographical distribution and specific genetic characteristics of HBV genotypes significantly impact disease pathogenesis and therapeutic strategies.