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Perfusion/diffusion quantitation with magnetic resonance imaging.

D R Pickens1

  • 1Department of Radiology and Radiological Sciences, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-2675.

Investigative Radiology
|December 1, 1992
PubMed
Summary
This summary is machine-generated.

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Magnetic resonance imaging (MRI) offers various techniques to quantify tissue perfusion and diffusion. Researchers are developing novel MRI methods to measure microcirculatory blood flow using pulse sequences, contrast agents, or blood as a tracer.

Area of Science:

  • Biomedical Engineering
  • Medical Imaging
  • Physiology

Background:

  • Quantifying tissue perfusion and diffusion using Magnetic Resonance Imaging (MRI) is a significant area of ongoing research.
  • Accurate measurement of microcirculatory flow is crucial for understanding various physiological and pathological processes.

Purpose of the Study:

  • To review and summarize diverse MRI-based techniques for quantifying tissue perfusion.
  • To highlight the advancements in developing methods for assessing microcirculatory blood flow.

Main Methods:

  • Development of specialized pulse sequences to detect proton movement associated with physiological perfusion.
  • Utilizing injected Magnetic Resonance (MR) contrast agents with high temporal resolution to generate time-density curves.
  • Employing blood itself as an endogenous tracer to determine perfusion parameters.

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Main Results:

  • Multiple MRI approaches provide quantitative data on microcirculatory flow.
  • Techniques vary in their reliance on pulse sequence design, contrast agents, or endogenous tracers.
  • All discussed methods aim to deliver accurate measurements of tissue perfusion.

Conclusions:

  • MRI offers a versatile toolkit for the quantitative assessment of tissue perfusion.
  • Ongoing research continues to refine and expand these non-invasive imaging techniques.
  • These advancements hold promise for improved diagnostic and therapeutic monitoring in clinical settings.