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Related Experiment Videos

Perfusion quantitation by ultrafast computed tomography.

R G Gould1

  • 1Department of Radiology, University of California, San Francisco 94143.

Investigative Radiology
|December 1, 1992
PubMed
Summary
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Ultrafast CT (UFCT) enables cardiac output measurement using contrast media. Improving accuracy for myocardial perfusion requires accounting for tissue blood volume and minimizing image artifacts.

Area of Science:

  • Medical Imaging
  • Cardiovascular Physiology
  • Radiology

Background:

  • Computed tomography (CT) scanners can measure blood flow using contrast media.
  • Ultrafast CT (UFCT) offers rapid scanning and data acquisition capabilities.
  • Indicator dilution principles are applicable for cardiac output measurement.

Purpose of the Study:

  • To evaluate the utility of UFCT for flow measurements.
  • To assess the feasibility of measuring myocardial perfusion with UFCT.
  • To identify challenges and potential improvements for UFCT-based flow quantification.

Main Methods:

  • Utilizing iodinated, nonionic contrast media as a first-pass indicator.
  • Employing UFCT with its short scan time (50 ms) and interscan delay (< or = 0.6 s).

Related Experiment Videos

  • Acquiring data at multiple cross-sectional levels without patient repositioning.

    • Main Results:

    • Cardiac output measurement using indicator dilution principles has been validated in animals and humans.
    • UFCT facilitates direct measurement of cardiac output.
    • Accurate measurement of myocardial perfusion remains challenging, with underestimation at high flow rates in animal experiments.

    Conclusions:

    • UFCT is suitable for cardiac output determination.
    • Further research is needed to enhance myocardial perfusion measurements.
    • Improving accuracy involves better accounting for tissue blood volume and reducing image artifacts.