Related Experiment Video
Updated: Aug 17, 2026

Real-time X-ray Imaging of Lung Fluid Volumes in Neonatal Mouse Lung
Published on: July 18, 2016
[Pulmonary mechanics in the full-term newborn]
Abstract:
The objective of this study is evaluate the pulmonary function in full term newborn infants, comparing classic with non-invasive techniques. We describe the pulmonary function laboratory and software developed at Instituto Fernandes Figueira. We studied 10 healthy full-term newborn infants (birthweight 3.260 g + - 460 g) Occlusions were performed at inspiration end and during expiration which allowed us to calculate values for total pulmonary resistance (TPR) and total pulmonary compliance (TPC). Esophageal pressure was measured with a water filled catheter positioned in the lower third of the esophagus, to obtain lung resistance (RL) and compliance (CL). All signals were digitized at 60 Hz into a microcomputer for further analysis. Mean results of our study are: CL= 1.78 + - 0.36 ml/cm H(2)O/kg, TPC= 1.12 + - 0.27 ml/cm H(2)O/kg and TPR= 16 + - 4 cm H(2)O/l/seg/kg. Our values are very similar to the ones in the current literature.
Related Concept Videos
Pressure Relationships in Thoracic Cavity
Breathing Mechanisms
Both intra-alveolar and intrapleural pressures rely on specific lung properties. The ability to breathe—allowing air to enter the lungs during...
Pulmonary Ventilation: Inhalation
Boyle's law becomes particularly pertinent when examining respiratory...
Pulmonary Cycle: Exhalation
Factors Affecting Pulmonary Ventilation
Alveolar Surface Tension
The alveolar fluid lines the luminal surface of the alveoli and exerts a force called surface tension. This force is caused by the polar water molecules in the liquid being more strongly attracted to each...
Respiratory Volumes and Capacities
Pulmonary Function Tests
Pulmonary Function Tests are crucial diagnostic tools for assessing respiratory function, particularly in patients with chronic respiratory disorders. They comprehensively evaluate lung volumes, ventilatory function, breathing mechanics, diffusion, and gas exchange. These tests help diagnose pulmonary diseases and play a significant role in monitoring disease progression, evaluating disability, and assessing response to therapy.
PFTs involve using a spirometer, a...

