Related Experiment Video

Updated: Aug 29, 2026

Protective Efficacy and Pulmonary Immune Response Following Subcutaneous and Intranasal BCG Administration in Mice
06:32

Protective Efficacy and Pulmonary Immune Response Following Subcutaneous and Intranasal BCG Administration in Mice

Published on: September 19, 2016

[Can the Mantoux test be used in BCG vaccinated children?]

E S Sarinho1, A S Aguiar Filho, A M Silva

  • 1Universidade Federal de Pernambuco.

Jornal De Pediatria
|March 1, 1994
PubMed

Insights

BCG vaccination in infants showed a 28.57% Mantoux reactivity rate in children, with 10 developing clinical tuberculosis. However, BCG did not significantly alter tuberculin test results in children under six years old.

Area of Science:

  • Pediatrics
  • Immunology
  • Infectious Diseases

Context:

  • Bacille Calmette-Guérin (BCG) vaccination is a primary method for preventing tuberculosis (TB) in infants.
  • Assessing the long-term efficacy and Mantoux tuberculin test reactivity post-BCG vaccination is crucial for TB control strategies.
  • Understanding the impact of BCG on tuberculin skin test (TST) results in early childhood is essential for accurate TB diagnosis.

Purpose:

  • To evaluate the Mantoux tuberculin test reactivity in children vaccinated with BCG in infancy.
  • To determine the incidence of clinical tuberculosis among BCG-vaccinated children with positive tuberculin tests.
  • To assess the influence of BCG vaccination on TST results across different age groups, particularly in children under six years old.

Summary:

  • A prospective trial involved 371 infants vaccinated with BCG, followed by Mantoux tuberculin testing.
  • Of the BCG-vaccinated children, 28.57% (106) showed Mantoux reactivity, with 10 diagnosed with clinical tuberculosis.
  • No significant difference in TST results was observed between BCG-vaccinated and non-vaccinated children under six; only 36.36% of two-year-olds reacted positively to PPD.

Impact:

  • The findings suggest BCG vaccination may have a limited impact on Mantoux reactivity in early childhood.
  • This research aids in refining TB diagnostic approaches and understanding BCG's protective effects in diverse pediatric populations.
  • Results highlight the need for further investigation into BCG efficacy and its interaction with tuberculin testing for effective global TB prevention.

More Related Videos

Micro-Colony Forming Unit Assay for Efficacy Evaluation of Vaccines Against Tuberculosis06:26

Micro-Colony Forming Unit Assay for Efficacy Evaluation of Vaccines Against Tuberculosis

Published on: July 28, 2023

A Suction Blister Protocol to Study Human T-cell Recall Responses In Vivo11:17

A Suction Blister Protocol to Study Human T-cell Recall Responses In Vivo

Published on: August 11, 2018

Related Concept Videos

Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Cancer Vaccines01:30

Cancer Vaccines

Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Assessing Body Temperature - Axilla01:14

Assessing Body Temperature - Axilla

Procedural Guide for Assessing Axillary Body Temperature using a Digital Thermometer:
Step 1: Perform hand hygiene and put on clean gloves to maintain infection control and prevent cross-contamination.
Step 2: Prepare the patient by explaining the procedure to ensure understanding and cooperation. Ensure privacy, expose the axilla, and inform the patient that minimal movement is crucial for an accurate reading.
Step 3: Adjust the patient’s clothing to expose only the axilla. It minimizes...