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[Ceftriaxione associated biliary lithiasis in newborns-report of two cases]

C M Rebello1, F de S Rossi, E J Troster

  • 1Berçário Anexo à Maternidade-Instituto da Crinça Prof. Pedro de Alcântra-Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo.

Jornal De Pediatria
|March 1, 1994
PubMed

Insights

Ceftriaxone use can cause biliary calculosis, a complication previously unreported in preterm neonates. Routine ultrasounds are recommended for neonates receiving ceftriaxone to detect this potential side effect.

Area of Science:

  • Neonatal Medicine
  • Pharmacology
  • Pediatric Gastroenterology

Context:

  • Biliary calculosis, or gallstones, is a known complication of ceftriaxone therapy.
  • Previous reports have documented this adverse effect in children and adults.
  • This complication had not been previously described in preterm neonates.

Purpose:

  • To report the first cases of ceftriaxone-associated biliary calculosis in preterm neonates.
  • To highlight the potential risk of this complication in a vulnerable population.
  • To advocate for enhanced monitoring in neonatal intensive care units.

Summary:

  • Two cases of preterm neonates developed biliary calculosis during ceftriaxone treatment.
  • Ceftriaxone, a commonly used antibiotic in neonatal intensive care units (NICUs), was implicated.
  • The findings suggest a need for increased vigilance regarding this adverse event.

Impact:

  • This study expands the known spectrum of ceftriaxone-associated adverse events.
  • It underscores the importance of routine ultrasonographic screening for neonates receiving ceftriaxone.
  • Early detection can prevent potential complications and guide treatment adjustments in neonatal care.

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