[Growth of premature infants fed own mother's milk supplied with two milk formulas]
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Updated: Aug 29, 2026

Individualized Reconstitution of Human Milk Microbiota: A Feasible Approach in Real-World Settings
Published on: February 7, 2025
H P Costa1, B I Kopelman, A C de Almeida
1Escola Paulista de Medicina, Universidade Federal de São Paulo.
Insights
Preterm formula supplementation significantly improved growth in premature infants, including those small for gestational age. This special formula supports better weight gain and head circumference development compared to modified formulas.
Area of Science:
- Neonatology
- Pediatric Nutrition
- Growth and Development
Background:
- Premature infants require specialized nutrition for optimal growth.
- Assessing the impact of different caloric formulas on premature infant growth is crucial.
Purpose of the Study:
- To evaluate the effects of two different caloric formulas on the growth of premature newborns.
- To compare the efficacy of a special preterm formula versus a modified formula in supporting infant growth.
Main Methods:
- Randomized controlled trial involving 70 premature infants (<1750g birth weight).
- Infants were categorized as adequate for gestational age (AGA) or small for gestational age (SGA).
- Anthropometric measurements and clinical evaluations were conducted at six key time points up to 40 weeks post-conceptional age.
Main Results:
- Premature infants receiving the special preterm formula showed greater daily weight gain and cephalic circumference increase compared to those on the modified formula.
- Both AGA and SGA infants demonstrated improved growth parameters with the preterm formula.
- SGA infants on the modified formula exhibited the poorest anthropometric outcomes.
Conclusions:
- The special preterm formula is more effective than the modified formula in promoting postnatal growth in both AGA and SGA premature infants.
- Individualized nutritional caloric planning is recommended for SGA premature infants due to their specific growth needs.
Abstract:
The purpose of the authors in this article was to evaluate the effects of supplementing maternal milk with two different caloric formulas on the growth of premature newborns until they reached 40 weeks of post-conceptional age. Seventy premature infants weighing < 1750g at birth were randomized: 35 adequate for gestational age (AGA) and 35 small for gestational age received maternal milk and either a special preterm formula or a modified formula. Anthropometric measurements and clinical evaluations were used to determine the nutritional status and the postnatal growth of these infants, who were analyzed in six different moments: at maximum weight loss, at return to birth weight, at definite weight gain, when exclusively fed with formula, at 2000g, and when they reached 40 weeks of post-conceptional age. The AGA premature newborns on preterm formula had greater daily weight gain, cephalic circumference increase and growth. The SGA premature newborns on preterm formula had greater daily weight gain and cephalic circumference increase observed from the third week of life onward. The AGA premature newborns on modified formula had less weight gain and smaller increments in the cephalic circumference. The SGA premature on modified formula had the worst anthropometric results. The preterm formula was more efficient than the modified formula in promoting postnatal growth of AGA and SGA premature infants. We believe that, due to their special characteristics, SGA premature should receive individualized nutritional caloric planning
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