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Friedreich ataxia-update on pathogenesis and possible therapies
Max Voncken1, Panos Ioannou, Martin B Delatycki
1Department of Cellular Animal Physiology, Subfaculty of Biology, Faculty of Science, University of Nijmegen, Nijmegen, The Netherlands.
Neurogenetics
|December 23, 2003
Abstract:
Friedreich ataxia is the most-common inherited ataxia. Since the causative genetic basis was described in 1996, much has been learnt about the pathogenesis from human, animal, and yeast studies. This has led to the development of rational therapeutic approaches. In this review, the current state of knowledge regarding the pathogenesis of Friedreich ataxia is presented and possible therapeutic strategies based on this knowledge are discussed.