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Emerging views of integrin signaling: implications for prostate cancer

Jill K Slack-Davis1, J Thomas Parsons

  • 1Department of Microbiology, University of Virginia Health Sciences System, Charlottesville, Virginia 22908, USA. jtp@virginia.edu

Journal of Cellular Biochemistry
|December 23, 2003
PubMed

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Integrins

Animal and protozoan cells do not have cell walls to help maintain shape and provide structural stability. Instead, these eukaryotic cells secrete a sticky mass of carbohydrates and proteins into the spaces between adjacent cells. This network of proteins and molecules is called an extracellular matrix or ECM.
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Interactions Between Signaling Pathways

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Overview of Cell-Matrix Interactions

The extracellular matrix or ECM holds cells together to form a tissue and allows the cells within the tissue to communicate. ECM comprises proteins such as fibronectin, collagen, laminin, etc. The most abundant protein in this space is collagen. Collagen fibers are interwoven with carbohydrate-containing protein molecules called proteoglycans. ECM allows cell migration and provides a structural scaffold at cell adhesion that anchors the cell when the extracellular matrix proteins interact with...
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