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[Factor V Leiden and the Slovak population].
J Hudecek1, M Dobrotová, J Hybenová
1Klinika hematológie a transfuziológie MFN a JLF UK, Martin, Slovenská republika.
Vnitrni Lekarstvi
|December 24, 2003
Summary
Factor V Leiden (FV Leiden) is a common cause of thrombosis. This study found a higher prevalence of FV Leiden in Slovak patients with thrombosis and myocardial infarction than in the healthy population.
Area of Science:
- Hematology
- Genetics
- Epidemiology
Context:
- Activated protein C resistance (APC-resistance) due to factor V Leiden (FV Leiden) is the most prevalent inherited thrombophilia in Caucasians.
- FV Leiden contributes to venous thromboembolism and exhibits significant geographic variation in Europe.
Purpose:
- This retrospective study aimed to determine the frequency of FV Leiden in the Slovak population.
- Investigate FV Leiden prevalence in healthy individuals, patients with a history of thrombosis, and patients with myocardial infarction (MI) with or without risk factors.
Summary:
- FV Leiden was detected in 4% of healthy Slovaks, aligning with European geographic distribution.
- Prevalence was significantly higher in patients with thrombosis (29.5%) compared to the general population and previously reported incidences (20%).
- In MI patients, FV Leiden occurred in 8.6% without risk factors and 14.6% with risk factors, suggesting a notable role in MI pathogenesis.
Impact:
- Findings indicate a higher-than-expected prevalence of FV Leiden in Slovak thrombotic and MI patient cohorts.
- This suggests an active role for the FV Leiden mutation in the pathogenesis of myocardial infarction, warranting further investigation.