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Cochinmicins, novel and potent cyclodepsipeptide endothelin antagonists from a Microbispora sp. I. Production,
Y K Lam1, D L Williams, J M Sigmund
1Merck Research Laboratories, Rahway, New Jersey 07065.
The Journal of Antibiotics
|November 11, 1992
Abstract:
Cochinmicins I, II, III are novel peptolides produced in submerged-fermentation cultures of Microbispora sp. ATCC 55140. These closely related compounds are separated by HPLC and are novel competitive endothelin antagonists. Cochinmicins II and III are stereoisomeric to each other. Cochinmicin I is the deschloro analog of cochinmicin III.