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[Effects of jing'an capsule on rat sperm quality]
Qing Wei1, Rui-Quan Fan, Xing-Fen Yang
1Department of Toxicology, School of Public Health, Sun Yet-San University, Guangzhou, Guangdong 510080, China.
Objective:
The effects of Jing'an capsule on the quality of rat sperm were studied to supply data for its safe clinical use.
Methods:
Eighty SD male rats were evenly and randomly divided into three test groups and one control group. Then the test groups were continuously given Jing'an capsule at different dosages: 557.1 mg/kg, 5,571 mg/kg or 11,420 mg/kg and the control group was given starch (20 g/L). Sixty days later, one of the epididymides, the sperm density was made and the sperm motility and morphology were investigated. The data obtained were analyzed by ANOVA, chi 2 test and Kruskal-Wallis test.
Results:
The sperm density, motility and morphology were variable at different dosages. Compared with the control, the sperm density increased significantly at the dosage of 557.1 mg/kg(P < 0.05), and a significant decrease was observed in the sperm density and motility (P < 0.05) at the dosage of 11,420 mg/kg. Although the rate of abnormal sperm morphology decreased at the dosage of 557.1 mg/kg and increased at the dosage of 5,571 mg/kg or 11,420 mg/kg compared with the control, there was no statistic significance(P < 0.05).
Conclusions:
A low dosage of Jing'an capsule might ameliorate the quality of sperm, while a high dosage could do damage to sperm.