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Related Experiment Videos

Carcinoid--a comprehensive review.

Isac I Schnirer1, James C Yao, Jaffer A Ajani

  • 1Department of Gastrointestinal Oncology and Digestive Diseases, The University of Texas M.D. Anderson Cancer Center, Houston, Texas 77005-4341, USA.

Acta Oncologica (Stockholm, Sweden)
|December 24, 2003
PubMed
Summary

Carcinoid tumors, arising from neuroendocrine cells, present varied clinical courses. While somatostatin analogues improve palliative care for carcinoid syndrome, advanced carcinoid tumors remain incurable, necessitating further research into targeted therapies.

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Area of Science:

  • Oncology
  • Molecular Biology
  • Medical Imaging

Background:

  • Carcinoid tumors originate from neuroendocrine cells and can exhibit indolent or aggressive behavior.
  • These tumors produce various peptides, influencing their clinical presentation and management.
  • Understanding carcinoid tumor biology, oncogenesis, and angiogenesis is crucial.

Purpose of the Study:

  • To comprehensively review carcinoid tumors, encompassing molecular biology, oncogenesis, angiogenesis, imaging, and therapy.
  • To analyze current literature on carcinoid tumors to identify knowledge gaps and future research directions.
  • To synthesize information on the management of carcinoid tumors and carcinoid syndrome.

Main Methods:

  • Systematic literature search of Medline and Cancerlit databases using 'carcinoid' as the keyword.

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  • Review of English language manuscripts, with 307 relevant references analyzed.
  • Screening of 7741 titles to identify pertinent studies on carcinoid tumors.

    • Main Results:

    • Management requires a multimodality approach, integrating understanding of the disease process.
    • Long-acting somatostatin analogues have advanced palliative care for carcinoid syndrome.
    • Advanced carcinoid tumors remain incurable, with current therapies showing limited efficacy or high toxicity.

    Conclusions:

    • Further research is essential in molecular biology, targeted therapy, and novel drug development for advanced carcinoid tumors.
    • Identifying clinical and biological predictors of outcome is critical for future advances.
    • Exploring the role of specific gene expressions (e.g., p53, VEGF) in tumor biology warrants further investigation.