Related Experiment Video
Updated: Jul 31, 2026

07:35
Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring
Published on: June 23, 2015
Glomerulocystic kidney disease in a kitten
Kenneth R Harkin1, David S Biller, Heather L Balentine
1Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506-5701, USA.
Journal of the American Veterinary Medical Association
|December 24, 2003
Summary
A rare kidney disease caused renomegaly and renal failure in a kitten. Glomerulocystic kidney disease should be considered when diagnostic tests are inconclusive.
Area of Science:
- Veterinary Pathology
- Nephrology
Background:
- Renomegaly and renal failure are serious conditions in young animals.
- Early-onset renal failure can be challenging to diagnose antemortem.
Observation:
- A 4-month-old kitten presented with enlarged kidneys and renal failure.
- Standard diagnostic methods, including ultrasonography and cytologic examination, were inconclusive.
- Histopathology revealed diffuse cystic dilatation of renal tubules and Bowman's spaces.
Findings:
- The observed lesions were histologically similar to human glomerulocystic kidney disease.
- This condition represents a rare cause of early-onset renal failure in felines.
- The kitten's presentation included renomegaly without detectable cysts on ultrasonography.
Implications:
- Glomerulocystic kidney disease should be included in the differential diagnosis for pediatric renal failure with renomegaly.
- Histopathological examination is crucial for definitive diagnosis when other methods fail.
- This case highlights the importance of considering rare genetic conditions in veterinary medicine.
Related Concept Videos
Nephrons
The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma happens...
Renal Corpuscle
The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous capillaries...
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous capillaries...
Kidney Transplant II: Surgical Procedure
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...

