Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Tumefactive lipedema with pseudoxanthoma elasticum-like microscopic changes.

Nancy E Taylor1, William C Foster, Mark R Wick

  • 1Department of Pathology, University of Virginia Health System, Charlottesville, VA, USA.

Journal of Cutaneous Pathology
|December 24, 2003
PubMed
Summary

This case report describes a rare tumefactive lipedema presentation in a 60-year-old woman. The findings suggest a potential link between lipedema and pseudoxanthoma elasticum (PXE).

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Partial Resuscitative Endovascular Balloon Occlusion of the Aorta Versus Intermittent Resuscitative Endovascular Balloon Occlusion of the Aorta in Noncompressible Torso Hemorrhage With Concomitant Traumatic Brain Injury.

Military medicine·2025
Same author

INVESTIGATING THE RELATIONSHIP BETWEEN BLEEDING, CLOTTING, AND COAGULOPATHY DURING AUTOMATED PARTIAL REBOA STRATEGIES IN A HIGHLY LETHAL PORCINE HEMORRHAGE MODEL.

Shock (Augusta, Ga.)·2024
Same author

A Comparative Analysis of "Surgery First" vs. "Endoscopy First" for Pediatric Choledocholithiasis Presenting at the End of the Week.

The American surgeon·2024
Same author

MAN VERSUS MACHINE: PROVIDER DIRECTED VERSUS PRECISION AUTOMATED CRITICAL CARE MANAGEMENT IN A PORCINE MODEL OF DISTRIBUTIVE SHOCK.

Shock (Augusta, Ga.)·2024
Same author

Contemporary outcomes for arterial reconstruction with non-saphenous vein cryo-preserved conduits.

Journal of vascular surgery·2024
Same author

Spare the Needle, Discharge the Child: Trending Post-Op Labs After Laparoscopic Common Bile Duct Exploration in Pediatric Patients Is Not Helpful.

The American surgeon·2024

Area of Science:

  • Dermatology
  • Genetics
  • Pathology

Background:

  • Lipedema is a chronic condition causing painful, symmetrical swelling in the legs and buttocks.
  • Microscopic features include edema, adipocyte degeneration, and mast cell infiltration.
  • Lipedematous alopecia shares some microscopic features with lipedema.

Observation:

  • A 60-year-old woman presented with bilateral leg masses and microscopic lipedema features.
  • Elastic-fiber changes, typical of pseudoxanthoma elasticum (PXE), were found in subcutaneous septa.
  • The patient had a history of hypertension and congestive heart failure but no other clinical PXE signs.

Findings:

  • This represents a previously undescribed tumefactive presentation of lipedema.
  • Elastic-tissue abnormalities suggest either subclinical PXE or secondary changes due to edema.

Related Experiment Videos

  • The findings may indicate an unusual manifestation of localized acquired cutaneous PXE (calcific elastosis).

    • Implications:

    • This case expands the understanding of lipedema's varied presentations.
    • It raises questions about potential genetic predispositions or secondary changes in lipedema.
    • Further research is needed to clarify the relationship between lipedema and PXE.