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Updated: Aug 29, 2026
Transradial Access Chemoembolization for Hepatocellular Carcinoma Patients
Published on: September 20, 2020
[Relation between vascular endothelial growth factor and reoccurence-metastasis after transcatheter arterial
Zheng-ping Xiong1, Shu-ren Yang, En-hua Xiao
1Department of Radiology, Xiang Ya Second Hospital, Central South University, Changsha 410011, China.
Objective:
To investigate the relation between changes in serum vascular endothelial growth factor (VEGF) level after transcatheter arterial chemoembolization (TACE) and hepatocellular carcinoma (HCC) progression, especially in relation to metastasis.
Methods:
Serum VEGF expression level, measured by quatitative sandwich enzyme-linked immunosorbent assay (ELISA, R&D system), was measured before, 3 days and 4 weeks after TACE in 30 patients with HCC. The development of metastasis was evaluated at the end of the third month after TACE.
Results:
1. The serum VEGF level in 30 patients was 154.47 +/- 90.17 pg/ml, 2. Post-TACE total serum VEGF level increased as compared with their basal level in 30 patients (P < 0.05) and serum VEGF level had a tendency to increase in patients with heterogeneous uptake of iodized oil and portal vein thrombosis. During the follow-up of 1 - 2 years, metastatic foci were found in 74% (20) patients with SVEGF increase, while none of the patients showing SVEGF decrease developed metastasis.
Conclusion:
Serum VEGF expression increase is associated with the development of metastasis in hepatocellular carcinoma after TACE.
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