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Patterns of beta-blocker utilization in patients with chronic heart failure: experience from a specialized outpatient
Ritesh Gupta1, W H Wilson Tang, James B Young
1Department of Internal Medicine, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA.
Insights
Beta-blocker utilization in heart failure patients reached 69% in a specialized clinic. Quality improvement initiatives can target subgroups with lower beta-blocker use, such as older patients or those with diabetes.
Area of Science:
- Cardiology
- Pharmacology
Background:
- Beta-blockers are proven to improve outcomes in heart failure patients.
- Limited data exists on beta-blocker use in real-world clinical practice.
- Utilization targets for quality improvement are not established.
Purpose of the Study:
- To assess beta-blocker utilization rates in a specialized heart failure clinic.
- To identify factors associated with lower beta-blocker use.
- To inform quality improvement initiatives.
Main Methods:
- Retrospective analysis of 500 chronic heart failure patients.
- Data extracted from electronic medical records.
- Inclusion criteria: specialized outpatient heart failure clinic patients.
Main Results:
- Beta-blocker utilization rate was 69%.
- Seventy-five percent of patients tried a beta-blocker; 16% experienced side effects.
- Lower utilization observed in elderly, diabetic patients, and those with preserved ejection fraction.
Conclusions:
- Approximately 70% of heart failure patients can be successfully treated with beta-blockers in specialized settings.
- Targeted quality improvement initiatives can address subgroups with lower utilization.
- Physician commitment to beta-blocker use is crucial for success.
Background:
Beta-blockers have been shown incontrovertibly to improve morbidity and survival in patients with heart failure. However, there is limited information regarding their use in clinical practice settings, and reasonable utilization targets for quality improvement initiatives have not been established.
Method:
We identified 500 consecutive patients with chronic heart failure seen at a specialized outpatient heart failure clinic from March 2001 to May 2001, and retrospectively extracted clinical and drug information from an electronic medical record.
Results:
In this cross-sectional analysis, the rate of beta-blocker utilization was 69%. Seventy-five percent of patients had at least tried a beta-blocker. Among those with beta-blockers initiated, 16% experienced side effects that led to drug discontinuation (9.1%) or down-titration (6.9%) that was similar across all NYHA classes. A lower utilization rate of beta-blockers was observed in patients of advanced age and those with diabetes mellitus, concomitant antiarrhythmic therapy, and preserved left ventricular ejection fraction (P <.05). Respiratory disease remained the most common reason for withholding beta-blocker therapy, especially with severe obstructive (rather than restrictive) physiology.
Conclusion:
It appears that about 70% of patients with chronic heart failure can be successfully treated with a beta-blocker in a specialized heart failure outpatient setting where physicians are committed to beta-blocker use in heart failure. It is possible that subgroups with lower utilization rates can be targeted for quality improvement initiatives.
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