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Crohn's disease presenting as unilateral labial hypertrophy
S L Werlin1, N B Esterly, H Oechler
1Department of Pediatrics, Medical College of Wisconsin, Milwaukee 53226.
Journal of the American Academy of Dermatology
|November 1, 1992
Summary
Unilateral vulvar hypertrophy in a child was linked to Crohn's disease, confirmed by biopsy. Treatment with sulfasalazine showed excellent response, highlighting a rare extraintestinal manifestation.
Area of Science:
- Pediatric Gastroenterology
- Dermatology
- Inflammatory Bowel Disease
Background:
- Crohn's disease (CD) is a chronic inflammatory bowel disease.
- Extraintestinal manifestations (EIMs) of CD can affect various organ systems.
- Vulvar involvement is an exceptionally rare EIM of CD.
Observation:
- A pediatric case presented with unilateral vulvar hypertrophy.
- Histopathological examination revealed noncaseating granuloma, characteristic of CD.
- Endoscopic findings showed punctate lesions with erythema in the rectum and sigmoid colon.
Findings:
- The patient exhibited a rare EIM of Crohn's disease (CD).
- Sulfasalazine treatment resulted in an excellent clinical response.
- Discontinuation of sulfasalazine led to the recurrence of gastrointestinal symptoms.
Implications:
- This case underscores the importance of considering CD in pediatric patients with unexplained vulvar hypertrophy.
- Early diagnosis and management of CD-related EIMs are crucial for patient outcomes.
- Highlights the diagnostic utility of biopsy and endoscopy in identifying rare manifestations of CD.