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Intravenous xylene poisoning.

P Sevcik¹, A Hep, M Peslová

¹Department of Anesthesiology and Intensive Care, Municipal Hospital, Brno, Czechoslovakia.

Intensive Care Medicine

|January 1, 1992

Summary

This summary is machine-generated.

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A man survived acute pulmonary failure after injecting xylene. Treatment focused on respiratory support and detoxification, leading to recovery within 14 days.

Area of Science:

Toxicology
Pulmonology
Critical Care Medicine

Background:

Xylene (methylbenzene) is an aromatic hydrocarbon solvent with potential for severe toxicity.
Intentional self-harm via intravenous injection of solvents is rare but carries high risk of systemic complications.

Observation:

A 30-year-old male presented with acute pulmonary failure 10 minutes after self-injecting 8 ml of xylene intravenously.
The patient required immediate intubation and mechanical ventilation with positive end-expiratory pressure (PEEP) and high fraction of inspired oxygen (FiO2).

Findings:

Combined hemoperfusion and hemodialysis were initiated for 4 hours to aid in xylene removal.
The patient demonstrated significant recovery, being weaned from mechanical ventilation by day 8 and discharged with normal blood gases by day 14.

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Implications:

This case highlights the critical and life-threatening nature of acute pulmonary failure following xylene injection.
Prompt respiratory support and extracorporeal detoxification methods (hemoperfusion/hemodialysis) can be life-saving in managing solvent-induced lung injury.
Management requires a multidisciplinary approach, prioritizing intensive respiratory care and toxicological intervention.