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Increased oxidative stress in patients with hydatidiform mole
Muge Harma1, Mehmet Harma, Ozcan Erel
1Department of Gynaecology, University of Harran, Faculty of Medicine, Sanliurfa, Turkey. harmam@ixir.com
Swiss Medical Weekly
|December 24, 2003
Summary
Patients with complete hydatidiform mole (CHM) experience increased oxidative stress, indicated by lower total antioxidant potential and higher peroxide levels compared to normal pregnancy. This suggests oxidative stress may contribute to CHM development.
Area of Science:
- Biochemistry
- Reproductive Medicine
- Pathophysiology
Background:
- Oxidative stress is implicated in various pathological conditions.
- Understanding oxidative status in pregnancy complications is crucial for diagnosis and management.
Purpose of the Study:
- To assess plasma oxidative and antioxidative status in patients with complete hydatidiform mole (CHM).
- To compare these markers between CHM patients and healthy pregnant women.
Main Methods:
- Plasma total antioxidant potential (TAOP) and total peroxide levels were measured in 38 CHM patients and 31 healthy pregnant women.
- Oxidative stress index was calculated as the ratio of TAOP to total peroxide.
Main Results:
- CHM patients exhibited significantly lower TAOP (511.9 vs. 571.7 µmol Trolox equiv./L) and higher total peroxide levels (21.8 vs. 15.6 µmol H2O2/L) compared to controls.
- The oxidative stress index was significantly elevated in CHM patients (4.43 vs. 2.92).
Conclusions:
- Complete hydatidiform mole is associated with significant oxidative stress.
- Oxidative stress may play a role in the pathogenesis of CHM.
- Antioxidant supplementation (Vitamins C and E) may be beneficial in managing CHM.