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[Young onset Parkinson's disease and smoking: meta-analysis]
M F Allam1, A S Del Castillo, R F-C Navajas
1Cátedra de Medicina Preventiva y Salud Pública, Universidad de Córdoba, Facultad de Medicina, Córdoba, España. fm2faahm@uco.es
Introduction:
Previous systemic reviews have reported a protective effect of smoking against Parkinson's disease (PD). However, the protective effect has not been examined before by any systemic review in patients with young onset PD.
Objective:
Examine the association between young onset PD and tobacco smoking.
Material And Methods:
We conducted a meta-analysis including all published observational studies that investigated this association before January 2003. All languages were included with no restriction for year of publication. Risk estimate and its 95% confidence interval (95% CI) were extracted or calculated for all localized studies in patients with young onset PD.
Results:
Five case-control studies investigated the association between young onset PD risk and ever smoking. The fixed-effect pooled analysis was 0.55 (95% CI: 0.38 0.81), with insignificant homogeneity test.
Conclusions:
This meta-analysis shows a protective effect of tobacco smoking against young onset PD. Our results coincide with the other reviews which did not consider the age of diagnosis of PD. However, it is highly recommended prospective studies for the association between young onset PD risk and ever smoking