[Animal models in the study of atherosclerosis]

When selecting an animal species for atherosclerosis research, the most important issue is matching the model to the experiment. In choosing the atherosclerosis model there is a wide variety of choices. Genetic hyperlipidemic disorders are best studied in Watanabe rabbits and in transgenic (knockout or overexpressed) mice. Interaction between clotting disorders and atherosclerosis can be evaluated in von Wilebrand's disease swine. If hypo- or hyper-responsiveness to atherogenic stimuli is to be investigated, one should consider the pigeons. Interactions between atherosclerosis and hypertension can be studied in rabbits and monkeys. Macaca nigra has proven to be very valuable in studies concerning the interactions between atherosclerosis and diabetes. Using suitable manipulation and other advantages, rabbits will yield significant insight into specific aspects of hypercholesterolemic effects and atherosclerosis.