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Bronchial epithelial-myoepithelial carcinoma
Kun Ru1, Amitabh Srivastava, Arthur S Tischler
1Department of Pathology, New England Medical Center, Tufts University School of Medicine, Boston, MA 02111, USA. kru@tufts-nemc.org
Archives of Pathology & Laboratory Medicine
|December 25, 2003
Summary
Epithelial-myoepithelial carcinoma is a rare lung tumor. This report details a case of intrabronchial epithelial-myoepithelial carcinoma in a heavy smoker, highlighting its histological features and immunohistochemical profile.
Area of Science:
- Pulmonary Pathology
- Oncology
- Rare Tumors
Background:
- Epithelial-myoepithelial tumors are exceedingly rare in the lungs, with only 20 cases documented previously.
- Malignant variants constitute the majority of reported pulmonary epithelial-myoepithelial tumors.
- This study focuses on a specific case of intrabronchial epithelial-myoepithelial carcinoma.
Observation:
- A 73-year-old male with a significant smoking history presented with an intrabronchial mass.
- The tumor was well-circumscribed, leading to distal airway obstruction.
- Histological examination revealed a biphasic pattern with glandular and solid areas.
Findings:
- Glands were lined by inner epithelial cells and outer myoepithelial cells.
- Solid areas comprised spindle-shaped myoepithelial cells.
- Immunohistochemistry showed positivity for p53 and c-Kit (CD117), with focal atypia and increased mitotic activity but no vascular invasion or nodal metastasis.
Implications:
- This case expands the understanding of rare pulmonary neoplasms.
- The findings contribute to the diagnostic criteria for epithelial-myoepithelial carcinoma in the lung.
- Further research may elucidate the specific oncogenesis and behavior of this rare tumor type.