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Related Experiment Videos

Reduction in dentin permeability using mildly supersaturated calcium phosphate solutions.

A M Cherng1, L C Chow, S Takagi

  • 1American Dental Association Health Foundation, Paffenbarger Research Center, National Institute of Standards and Technology, Gaithersburg, MD 20899, USA.

Archives of Oral Biology
|December 25, 2003
PubMed
Summary

Multiple treatments with a calcium phosphate solution significantly reduced hydraulic conductance (Lp) in dentin discs. This suggests a potential new method for managing dentin hypersensitivity by further occluding dentin tubules.

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Area of Science:

  • Dentistry
  • Biomaterials Science

Background:

  • Dentin hypersensitivity is a common clinical issue.
  • Obturating dentin tubules is a key strategy for managing hypersensitivity.
  • Previous treatments have focused on tubule occlusion.

Purpose of the Study:

  • To evaluate the efficacy of multiple treatments with a calcium phosphate solution.
  • To assess the impact on hydraulic conductance (Lp) of dentin.
  • To determine the effectiveness in partially occluded dentin discs in vitro.

Main Methods:

  • Used partially occluded dentin discs in vitro.
  • Applied a mildly supersaturated calcium phosphate solution multiple times.
  • Measured hydraulic conductance (Lp) before and after treatments.

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  • The solution contained calcium, phosphate, fluoride, KCl, and HEPES buffer at pH 7.0.

    • Main Results:

    • Mean baseline Lp was 0.108+/-0.041.
    • After five treatments, relative Lp decreased progressively: 71%, 58%, 46%, 40%, and 25%.
    • Significant differences (P<0.05) were observed between baseline and treatment groups.

    Conclusions:

    • Consecutive treatments with the calcium phosphate solution effectively reduced dentin hydraulic conductance.
    • This approach shows promise for further occluding dentin tubules.
    • The findings support the potential of this treatment for dentin hypersensitivity management.