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Published on: July 3, 2015
Protective effect of Spirulina fusiformis on chemical-induced genotoxicity in mice
K Premkumar1, S K Abraham, S T Santhiya
1Department of Genetics, Dr. ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani, Chennai 600-113, India. pkumpati@yahoo.co.in
Abstract:
Spirulina fusiformis given by oral route to mice at doses of 250, 500 and 1000 mg kg(-1) significantly inhibit the genotoxicity induced by cisplatin and urethane. In addition, a significant reduction in the extent of lipid peroxidation with concomitant increase in the liver enzymatic (GPx, GST, SOD, CAT) and non-enzymatic (reduced glutathione) antioxidants were observed.

