Paeoniflorin: an antihyperlipidemic agent from Paeonia lactiflora
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Updated: Aug 29, 2026

Network Pharmacology Prediction and Metabolomics Validation of the Mechanism of Fructus Phyllanthi against Hyperlipidemia
Published on: April 7, 2023
Hyun Ok Yang1, Woo Kyung Ko, Jae Youn Kim
1Department of Molecular Medicine, Asan Institute for Life Sciences, University of Ulsan, Seoul 138-736, South Korea. hoyang@amc.seoul.kr
Abstract:
Paeoniflorin (1), isolated from the methanol extract of Paeonia lactiflora, showed a lowering effect on cholesterol level in the experimentally-induced hyperlipidemic rats. Paeoniflorin showed a significantly lowering effect of total cholesterol, LDL and triglyceride levels compared with the control group at the dose of 200 and 400 mg/kg, p.o. once a day for 4 weeks.
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