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Bioactive flavonoids from Kaempferia parviflora.
Chavi Yenjai1, Khanchara Prasanphen, Supawadee Daodee
1Faculty of Sciences, Khon Kaen University, Khon Kaen 40002, Thailand. chayen@kku.ac.th
Fitoterapia
|December 25, 2003
Summary
Kaempferia parviflora yielded nine flavonoids. Two flavonoids showed significant antiplasmodial activity against Plasmodium falciparum, while others demonstrated antifungal and antimycobacterial effects without cytotoxicity.
Area of Science:
- Natural Products Chemistry
- Pharmacology
- Medicinal Chemistry
Background:
- Kaempferia parviflora is a traditional medicinal plant.
- Flavonoids are a diverse class of plant secondary metabolites with various biological activities.
Purpose of the Study:
- To isolate and characterize flavonoids from Kaempferia parviflora.
- To evaluate the antiplasmodial, antifungal, antimycobacterial, and cytotoxic activities of the isolated compounds.
Main Methods:
- Phytochemical investigation of Kaempferia parviflora.
- Isolation and structural elucidation of nine flavonoids.
- In vitro assays for antiplasmodial, antifungal, antimycobacterial, and cytotoxicity.
Main Results:
- Nine flavonoids were isolated from Kaempferia parviflora.
- 5,7,4'-trimethoxyflavone (8) and 5,7,3',4'-tetramethoxyflavone (9) showed potent antiplasmodial activity (IC50 = 3.70 and 4.06 microg/ml).
- 3,5,7,4'-Tetramethoxyflavone (7) and compound 8 exhibited antifungal activity against Candida albicans and mild antimycobacterial activity.
Conclusions:
- Kaempferia parviflora is a source of bioactive flavonoids.
- The isolated flavonoids, particularly 5,7,4'-trimethoxyflavone and 5,7,3',4'-tetramethoxyflavone, hold potential for developing new antimalarial agents.
- Further research into the antifungal and antimycobacterial properties of these flavonoids is warranted.