(Unlearned) lessons from John Graunt and Kenneth Rothman: a "CLASSic" example
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Drosophila Passive Avoidance Behavior as a New Paradigm to Study Associative Aversive Learning
Published on: October 15, 2021
Felix M Arellano1, Jordi Castellsague,
1Drug Safety Surveillance, Pfizer Inc, Peapack, New Jersey 07977, USA. felix.m.arellano@pfizer.com
Abstract:
This commentary reviews the work of John Graunt and Kenneth J. Rothman on statistical significance and the need for prespecification of study end points. The authors argue that it is dangerous to substitute oversimplifications based exclusively on whether a result has reached statistical significance for a rational process of causal inference. An example is given based on the Celecoxib Long-term Arthritis Safety Study.
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E. C. Tolman's theory of purposive behavior emphasizes that much behavior is goal-directed. He argued that to understand behavior, we must look at the entire sequence of actions leading to a goal. For instance, high school students study hard, not just due to past reinforcement but also to achieve the goal of getting into a good college.
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