Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Microinvasive squamous cell cervical carcinoma.

Francesco Raspagliesi1, Antonino Ditto, Eugenio Solima

  • 1Department of Gynecologic Oncology, Istituto per lo Studio e la Cura dei Tumori, Via Venezian 1, 20133 Milan, Italy. dittotony@hotmail.com

Critical Reviews in Oncology/Hematology
|December 25, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The TRUST trial in ovarian cancer: a missed opportunity or a turning point? The position of the Italian MITO group.

Frontiers in oncology·2026
Same author

Revisiting the Concept of Nerve-Sparing Radical Hysterectomy: A Proof-of-Concept Prospective Study From a Cervical Cancer Cohort.

Annals of surgical oncology·2026
Same author

Immunotherapy with anti-PD-1 or PD-L1 in advanced ovarian cancer: A meta-analysis of randomized trials.

Cancer treatment reviews·2026
Same author

Effectiveness of azacytidine for poly ADP-ribose polymerase inhibitor-induced myelodysplastic syndrome in ovarian cancer patient: a twofold triumph.

Journal of chemotherapy (Florence, Italy)·2026
Same author

Fertility-sparing vs hysterectomy for uterine STUMP: A pragmatic clinical study.

European journal of cancer (Oxford, England : 1990)·2026
Same author

ASO Author Reflections: Probe-Based Confocal Laser Endomicroscopy for Intraoperative Tissue Assessment in Gynecologic Oncology.

Annals of surgical oncology·2026
Same journal

Estrobolome and the Endocrine-Microbiome Axis in Breast and Endometrial Carcinogenesis.

Critical reviews in oncology/hematology·2026
Same journal

Remodeling the immune microenvironment: Engineering IL-2 variants to overcome clinical bottlenecks in PD-1 inhibitor plus chemotherapy.

Critical reviews in oncology/hematology·2026
Same journal

Neoadjuvant immunotherapy in melanoma: From pathologic response to response-adapted management.

Critical reviews in oncology/hematology·2026
Same journal

DNA polymerase epsilon catalytic subunit (POLE) in cancer: Implications for tumor biology and therapeutic strategies - A comprehensive review.

Critical reviews in oncology/hematology·2026
Same journal

Long non-coding RNAs in triple-negative breast cancer: emerging drivers of tumor biology, prognosis, and drug resistance.

Critical reviews in oncology/hematology·2026
Same journal

Alternative splicing in breast cancer drug resistance: Mechanisms, therapeutic targeting, and clinical translation.

Critical reviews in oncology/hematology·2026
See all related articles

For microinvasive cervical cancer (MIC), clear margins after conization are crucial. Adequate lateral clearance significantly reduces recurrence risk, potentially making conization definitive treatment.

Area of Science:

  • Gynecologic Oncology
  • Pathology
  • Surgical Oncology

Background:

  • Histologic features of microinvasive cervical cancer (MIC) guide treatment planning post-conization.
  • Accurate prognostic factors are needed to define conservative treatment indications for MIC.

Purpose of the Study:

  • To review prognostic factors for MIC.
  • To prospectively evaluate pathologic factors, tumor-cone margin relationships, and recurrence incidence in MIC patients.

Main Methods:

  • Literature review for prognostic factors in MIC.
  • Prospective observational study of MIC patients.
  • Evaluation of depth of infiltration, lymph-vascular involvement, and apical/lateral margin clearance.

Main Results:

Related Experiment Videos

  • Seven recurrences were observed in the study cohort.
  • Patients were stratified by apical (10 mm) and lateral (8 mm) margin clearance.
  • Depth of infiltration and lymph-vascular involvement are key prognostic histologic parameters.
  • Apical and lateral margin clearance significantly correlate with recurrence rates.

Conclusions:

  • Adequate lateral margin clearance on the cone specimen is a significant predictor of recurrence.
  • Conization may be considered definitive treatment for MIC when sufficient lateral healthy tissue is achieved.